RGL1 and RIT2

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (in vitro)

		RGL1	RIT2
Gene Name		ral guanine nucleotide dissociation stimulator-like 1	Ras-like without CAAX 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Nucleus Plasma Membrane
	Molecular Function	Ral Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Calmodulin Binding GTP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Ral GTPase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Response to antidepressants ( 20360315)	Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-Protein Interactions		4 interactors: APP HRAS RIT1 RIT2	12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		23179	6014
HPRD ID		12032	15253
Ensembl ID		ENSG00000143344	ENSG00000152214
Uniprot IDs		B7Z2W5 F5H6U6 Q9NZL6	Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Visual Learning Axonogenesis Visual Behavior Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Small GTPase Mediated Signal Transduction Associative Learning Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Olfactory Bulb Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Learning Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Striatal Medium Spiny Neuron Differentiation Synaptic Growth At Neuromuscular Junction Cell Morphogenesis Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Ras Protein Signal Transduction Locomotion Positive Regulation Of Transcription, DNA-templated Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Rac Protein Signal Transduction Regulation Of Epithelial Cell Proliferation Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of MiRNA Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axon Choice Point Recognition Positive Regulation Of Ruffle Assembly Generation Of Neurons Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process	Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity
Tagcloud ?			advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Difference) ?			advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Intersection) ?