HIC2 and HIC1

Number of citations of the paper that reports this interaction (PMID 11554746)
10

Data Source:
BioGRID (two hybrid, imaging technique)

		HIC2	HIC1
Gene Name		hypermethylated in cancer 2	hypermethylated in cancer 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane	Chromatin Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Protein C-terminus Binding Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS		Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Protein-Protein Interactions		4 interactors: APP CCNT1 HIC1 PDK2	12 interactors: ARID1A CTBP1 CTBP2 HDAC1 HIC2 PIAS1 SENP3 SIRT1 STAT3 TCF4 UBC UBE2I
Entrez ID		23119	3090
HPRD ID		07412	04826
Ensembl ID		ENSG00000169635	ENSG00000177374
Uniprot IDs		Q96JB3	A0PJI1 Q14526
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Cell Death Death Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Axon Choice Point Recognition Apoptotic Signaling Pathway Neuron Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Phosphorylation Response To Oxidative Stress Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Copper Ion Homeostasis Ion Homeostasis Signaling Cell Communication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Kinase Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Cellular Response To Nutrient Regulation Of Kinase Activity Phosphate-containing Compound Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Gluconeogenesis Chemical Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Fat Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Androgen Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process
Tagcloud ?			ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped highlighting interconnected ipa jun krt8 mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Difference) ?			ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped highlighting interconnected ipa jun krt8 mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Intersection) ?