HIC1 and ARID1A

Number of citations of the paper that reports this interaction (PMID 19486893)
13

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HIC1	ARID1A
Gene Name		hypermethylated in cancer 1	AT rich interactive domain 1A (SWI-like)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex NpBAF Complex NBAF Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Transcription Coactivator Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Nucleosome Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Cardiac Chamber Development Optic Cup Formation Involved In Camera-type Eye Development Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Forebrain Development Nucleosome Mobilization Glucocorticoid Receptor Signaling Pathway ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Placenta Blood Vessel Development Toxin Transport
Pathways			Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARID1A CTBP1 CTBP2 HDAC1 HIC2 PIAS1 SENP3 SIRT1 STAT3 TCF4 UBC UBE2I	11 interactors: GATA1 HIC1 ITCH KLF1 MLLT1 NEDD4 PGR RARA SMARCA4 SRC TP53
Entrez ID		3090	8289
HPRD ID		04826	04319
Ensembl ID		ENSG00000177374	ENSG00000117713
Uniprot IDs		A0PJI1 Q14526	O14497
PDB IDs			1RYU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Fat Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Androgen Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process	Progesterone Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Embryonic Organ Development Positive Regulation Of Cellular Biosynthetic Process Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Regulation Of Binding Cellular Response To Organic Substance Hemopoiesis Cell Fate Commitment Organ Development Positive Regulation Of Signal Transduction Immune System Development Regulation Of Signaling Regulation Of Phosphorylation Immune System Process RNA Metabolic Process Regulation Of Protein Metabolic Process Erythrocyte Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Intracellular Signal Transduction Erythrocyte Homeostasis
Tagcloud ?		ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped highlighting interconnected ipa jun krt8 mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple	9p24 actionable atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped highlighting interconnected ipa jun krt8 mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple	9p24 actionable atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite mlh1 msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?