SETD1B and HIST1H3E

Number of citations of the paper that reports this interaction (PMID 17355966)
63

Data Source:
BioGRID (enzymatic study)

		SETD1B	HIST1H3E
Gene Name		SET domain containing 1B	histone cluster 1, H3e
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: HIST1H3A HIST1H3E HIST2H3C WDR5	10 interactors: ASF1A ASF1B CHAF1A CHAF1B DNMT3A PHF1 RPS6KA5 SETD1B TRIM24 UHRF1
Entrez ID		23067	8353
HPRD ID		19516	11907
Ensembl ID		ENSG00000139718	ENSG00000196966
Uniprot IDs		F6MFW1 Q9UPS6	P68431
PDB IDs		3UVO 4ES0	1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing DNA Methylation Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Chromatin Organization Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromosome Organization DNA Metabolic Process DNA Packaging Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Conformation Change Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gluconeogenesis	Chromatin Organization DNA Replication-dependent Nucleosome Assembly Chromosome Organization Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organelle Organization Nucleosome Assembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Assembly Nucleosome Organization Gene Expression Transcription, DNA-templated Chromatin Assembly Or Disassembly RNA Biosynthetic Process Protein-DNA Complex Assembly DNA Packaging Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process DNA Conformation Change RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process DNA Methylation On Cytosine Macromolecule Biosynthetic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process DNA Metabolic Process DNA Repair Biosynthetic Process DNA Replication-independent Nucleosome Assembly Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Cellular Metabolic Process DNA Methylation Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Histone H2A-S1 Phosphorylation Histone Modification Methylation Protein Complex Assembly DNA Modification Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		11q13 aberrations adam29 ash1l assayed cdkn2a consortium crebbp drinking ep300 escc exome fam135b histopathological kmt2c kmt2d microrna mir548k mll2 mll3 nfe2l2 notch1 oesophageal pik3ca rb1 repertoire sixth tumorigenic vast
Tagcloud (Difference) ?		11q13 aberrations adam29 ash1l assayed cdkn2a consortium crebbp drinking ep300 escc exome fam135b histopathological kmt2c kmt2d microrna mir548k mll2 mll3 nfe2l2 notch1 oesophageal pik3ca rb1 repertoire sixth tumorigenic vast
Tagcloud (Intersection) ?