CNOT1 and CNOT3

Number of citations of the paper that reports this interaction (PMID 16778766)
20

Data Source:
HPRD (in vivo)

		CNOT1	CNOT3
Gene Name		CCR4-NOT transcription complex, subunit 1	CCR4-NOT transcription complex, subunit 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Extracellular Space Nucleoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex	Cytoplasmic MRNA Processing Body Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Protein Complex Scaffold Retinoic Acid Receptor Binding Poly(A) RNA Binding Armadillo Repeat Domain Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Multicellular Organismal Development Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Maintenance	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Gene Expression Gene Silencing By RNA Regulation Of Stem Cell Maintenance
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		QT interval ( 22726844 19305408)
Protein-Protein Interactions		8 interactors: CNOT2 CNOT3 CNOT4 CNOT8 PPARG RARA RXRA THRB	7 interactors: CAND1 CAND2 CNOT1 CNOT2 CNOT8 CREBBP ID3
Entrez ID		23019	4849
HPRD ID		11999	05368
Ensembl ID		ENSG00000125107	ENSG00000088038
Uniprot IDs		A5YKK6	O75175
PDB IDs		4GMJ 4GML 4J8S
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing Regulation Of Translation Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway RNA 3'-end Processing Hormone-mediated Signaling Pathway Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Gene Expression RNA Catabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Gene Silencing By RNA Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Gene Silencing Cellular Response To Organic Cyclic Compound Cellular Response To Lipid MRNA Processing Response To Retinoic Acid Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Stem Cell Maintenance Trophectodermal Cell Differentiation RNA Processing Cellular Response To Hormone Stimulus Response To Vitamin A	Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Exonucleolytic SCF Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA MRNA 3'-end Processing Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of RNA Metabolic Process MRNA Catabolic Process Negative Regulation Of Gene Expression Regulation Of Stem Cell Maintenance Positive Regulation Of MRNA Catabolic Process RNA Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Silencing By MiRNA Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Translation Posttranscriptional Gene Silencing Gene Expression Positive Regulation Of Cellular Component Biogenesis Cellular Macromolecule Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Macromolecule Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread
Tagcloud (Difference) ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread
Tagcloud (Intersection) ?