CNOT1

Gene Name		CCR4-NOT transcription complex, subunit 1
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Extracellular Space Nucleoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Protein Complex Scaffold Retinoic Acid Receptor Binding Poly(A) RNA Binding Armadillo Repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Multicellular Organismal Development Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Maintenance
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		QT interval ( 22726844 19305408)
Protein-protein Interactions		8 interactors: CNOT2 CNOT3 CNOT4 CNOT8 PPARG RARA RXRA THRB
Entrez ID		23019
HPRD ID		11999
Ensembl ID		ENSG00000125107
Uniprot IDs		A5YKK6
PDB IDs		4GMJ 4GML 4J8S
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing Regulation Of Translation Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway RNA 3'-end Processing Hormone-mediated Signaling Pathway Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Gene Expression RNA Catabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Gene Silencing By RNA Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Gene Silencing Cellular Response To Organic Cyclic Compound Cellular Response To Lipid MRNA Processing Response To Retinoic Acid Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Stem Cell Maintenance Trophectodermal Cell Differentiation RNA Processing Cellular Response To Hormone Stimulus Response To Vitamin A
Tagcloud ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread