NT5C2 and NUDT18

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NT5C2	NUDT18
Gene Name		5-nucleotidase, cytosolic II	nudix (nucleoside diphosphate linked moiety X)-type motif 18
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding Nucleoside Phosphotransferase Activity	Magnesium Ion Binding Protein Binding 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity
	Biological Process	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Phosphorylation Dephosphorylation Drug Metabolic Process Small Molecule Metabolic Process IMP Metabolic Process Adenosine Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Nucleobase-containing Small Molecule Catabolic Process Small Molecule Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Purine catabolism Purine metabolism Metabolism of nucleotides Abacavir transport and metabolism Abacavir metabolism
Drugs		Adenosine triphosphate Ribavirin
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21572416 21909110) Coronary heart disease ( 21378990) Schizophrenia ( 21926974 22688191 23894747) Systolic blood pressure ( 19430483 21909115)
Protein-Protein Interactions		10 interactors: ATP5O CALM1 FXR2 MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP	34 interactors: APIP COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 SDPR TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		22978	79873
HPRD ID		02686	07992
Ensembl ID		ENSG00000076685
Uniprot IDs		A8K6K2 B7Z382 P49902	Q6ZVK8
PDB IDs		2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B	3GG6
Enriched GO Terms of Interacting Partners?		Purine Nucleoside Metabolic Process Ribonucleotide Metabolic Process Nucleoside Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Organophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Regulation Of High Voltage-gated Calcium Channel Activity Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ribonucleoside Diphosphate Catabolic Process Establishment Of Localization In Cell Nucleoside Diphosphate Catabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Detection Of Calcium Ion Substrate-dependent Cell Migration, Cell Extension Energy Derivation By Oxidation Of Organic Compounds Nucleotide Biosynthetic Process Purine Ribonucleoside Catabolic Process Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Protein Homooligomerization Protein Oligomerization Nucleoside Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Protein Homotetramerization Nitrogen Compound Metabolic Process Catabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Purine Nucleoside Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity IMP Metabolic Process Alpha-amino Acid Metabolic Process Nucleotide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide Metabolic Process Polyamine Metabolic Process Cofactor Metabolic Process Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Protein Autoubiquitination Purine Nucleobase Metabolic Process Sulfur Amino Acid Metabolic Process DUMP Biosynthetic Process Deoxyhypusine Biosynthetic Process From Spermidine DUTP Catabolic Process Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Amino Acid Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Glutamine Biosynthetic Process MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Spermidine Catabolic Process L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Modified Amino Acid Metabolic Process Pyrimidine Nucleotide Metabolic Process Pyrimidine Nucleoside Metabolic Process Targeting Of MRNA For Destruction Involved In RNA Interference DUMP Metabolic Process NADP Biosynthetic Process DUTP Metabolic Process Negative Regulation Of Cilium Assembly
Tagcloud ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Difference) ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Intersection) ?