NT5C2 and NME7

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NT5C2	NME7
Gene Name		5-nucleotidase, cytosolic II	NME/NM23 family member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Centrosome Ciliary Basal Body
	Molecular Function	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding Nucleoside Phosphotransferase Activity	Nucleoside Diphosphate Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Phosphorylation Dephosphorylation Drug Metabolic Process Small Molecule Metabolic Process IMP Metabolic Process Adenosine Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Epithelial Cilium Movement Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Determination Of Left/right Symmetry Brain Development Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Left/right Pattern Formation
Pathways		Purine catabolism Purine metabolism Metabolism of nucleotides Abacavir transport and metabolism Abacavir metabolism
Drugs		Adenosine triphosphate Ribavirin
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21572416 21909110) Coronary heart disease ( 21378990) Schizophrenia ( 21926974 22688191 23894747) Systolic blood pressure ( 19430483 21909115)	D-dimer levels ( 21502573) Venous thromboembolism ( 21980494 22672568)
Protein-Protein Interactions		10 interactors: ATP5O CALM1 FXR2 MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP	27 interactors: C1orf189 CCHCR1 CDC42EP2 CEP72 DDX1 FKBP6 FOSL1 GOLGA2 KIAA1598 KRT18 LNX1 MAP4K4 MYOT NAB2 NEFL NT5C2 OFD1 REL SYCE1 TCF4 TCHP TNIP1 TRIM27 TUFT1 YWHAQ ZBTB48 ZNF263
Entrez ID		22978	29922
HPRD ID		02686	11394
Ensembl ID		ENSG00000076685	ENSG00000143156
Uniprot IDs		A8K6K2 B7Z382 P49902	Q9Y5B8
PDB IDs		2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B
Enriched GO Terms of Interacting Partners?		Purine Nucleoside Metabolic Process Ribonucleotide Metabolic Process Nucleoside Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Organophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Regulation Of High Voltage-gated Calcium Channel Activity Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ribonucleoside Diphosphate Catabolic Process Establishment Of Localization In Cell Nucleoside Diphosphate Catabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Detection Of Calcium Ion Substrate-dependent Cell Migration, Cell Extension Energy Derivation By Oxidation Of Organic Compounds Nucleotide Biosynthetic Process Purine Ribonucleoside Catabolic Process Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Cell Cycle Response To Corticosterone Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Mineralocorticoid Negative Regulation Of Transcription, DNA-templated Intermediate Filament Cytoskeleton Organization Negative Regulation Of Nucleic Acid-templated Transcription Organelle Organization Negative Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Intermediate Filament-based Process Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Golgi To Plasma Membrane CFTR Protein Transport Bone Mineralization Body Morphogenesis Developmental Process Transcription, DNA-templated Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Interleukin-2 Secretion Gamma-tubulin Complex Localization Catenin Import Into Nucleus Vitellogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Cellular Component Assembly Negative Regulation Of Viral Process Biomineral Tissue Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Neurofilament Bundle Assembly Ossification Regulation Of Cellular Component Organization Maintenance Of DNA Repeat Elements RNA Metabolic Process Intracellular Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Regulation Of Cellular Component Size Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Secretion
Tagcloud ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb overlapped pharmacogenomics plcd3 plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?