PPM1E and TNIK

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		PPM1E	TNIK
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1E	TRAF2 and NCK interacting kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive test performance ( 17903297) Testicular germ cell tumor ( 23666239)	Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		4 interactors: ARHGEF7 DISC1 GAPDH TNIK	38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		22843	23043
HPRD ID		17888	18206
Ensembl ID			ENSG00000154310
Uniprot IDs		A7E2X1 Q8WY54	Q9UKE5
PDB IDs			2X7F
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Organization Peptidyl-cysteine S-trans-nitrosylation Regulation Of Cell Development Cytoskeleton Organization Positive Regulation Of Lamellipodium Morphogenesis Peptidyl-cysteine S-nitrosylation Wnt Signaling Pathway Cell Projection Assembly Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Regulation Of Cell Differentiation Neurogenesis Activation Of JNKK Activity Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Migration Intracellular Signal Transduction Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Morphogenesis Microvillus Assembly Positive Regulation Of Cell Development Microvillus Organization Mitochondrial Calcium Ion Homeostasis Regulation Of Protein Metabolic Process Positive Regulation Of Lamellipodium Organization Regulation Of Neuron Differentiation Regulation Of Synapse Maturation Nervous System Development TOR Signaling Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neurogenesis Focal Adhesion Assembly Regulation Of Fibroblast Migration Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Signal Transduction Microtubule-based Process Cellular Response To Stimulus Lamellipodium Assembly Positive Regulation Of Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Assembly Regulation Of Signaling Lamellipodium Organization Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Cell Proliferation In Forebrain Organelle Organization	Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation
Tagcloud ?		2c ac acetylated aging alters bipolar decarboxylase gad1 glutamic h3k9k14 hdac homolog htr2c hydroxytryptamine hypoacetylation lysines marks neuropsychiatric outer postmortem prefrontal psychiatric qpcr schizophrenia tomm70a transcriptionally translocase whereby	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?		2c ac acetylated aging alters bipolar decarboxylase gad1 glutamic h3k9k14 hdac homolog htr2c hydroxytryptamine hypoacetylation lysines marks neuropsychiatric outer postmortem prefrontal psychiatric qpcr schizophrenia tomm70a transcriptionally translocase whereby	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?