RASSF5 and RRAS

Number of citations of the paper that reports this interaction (PMID 11857081)
43

Data Source:
HPRD (in vitro, in vivo)

		RASSF5	RRAS
Gene Name		Ras association (RalGDS/AF-6) domain family member 5	related RAS viral (r-ras) oncogene homolog
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Protein Localization To Nucleus	Leukocyte Differentiation Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade
Pathways			Axon guidance Semaphorin interactions Activation of NMDA receptor upon glutamate binding and postsynaptic events SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		31 interactors: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MAP1S MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK3 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 VPS28	15 interactors: ACY3 ARAF BCL2 EEF1A1 EPHB2 MLLT4 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1
Entrez ID		83593	6237
HPRD ID		06117	01299
Ensembl ID		ENSG00000136653	ENSG00000126458
Uniprot IDs		Q8WWW0	P10301
PDB IDs		4LGD	2FN4
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Signaling Cell Communication Regulation Of Signaling Response To Stimulus Branching Morphogenesis Of An Epithelial Tube Regulation Of Phosphorylation Rap Protein Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Epithelial Tube Morphogenesis Morphogenesis Of A Branching Epithelium Regulation Of MAPK Cascade Morphogenesis Of A Branching Structure Regulation Of Phosphorus Metabolic Process Tube Morphogenesis Endocardium Development Regulation Of Cell Death Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Neuron Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Morphogenesis Of An Epithelium Positive Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hippo Signaling Neurotrophin Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Tissue Morphogenesis Regulation Of Synaptic Transmission, GABAergic	Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Signal Transduction Regulation Of Catalytic Activity Neuron Projection Morphogenesis Optic Nerve Development Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Small GTPase Mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Autophagy Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Neuron Development Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Cell Death Neurotrophin Signaling Pathway Death Cell Morphogenesis Regulation Of Protein Phosphorylation
Tagcloud ?		action activates acts allows arrest catenin dictate effector exhibit explanation frequently ikappab ligase lost nore1a observation oncogene promoted promoting proteasome scf stimulate substrate suppressor toward trcp ubiquitin wnt	10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision exome favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert
Tagcloud (Difference) ?		action activates acts allows arrest catenin dictate effector exhibit explanation frequently ikappab ligase lost nore1a observation oncogene promoted promoting proteasome scf stimulate substrate suppressor toward trcp ubiquitin wnt	10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision exome favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert
Tagcloud (Intersection) ?