FKBP1A and TGFBR1

Number of citations of the paper that reports this interaction (PMID 7518616)
39

Data Source:
HPRD (two hybrid, in vitro)

		FKBP1A	TGFBR1
Gene Name		FK506 binding protein 1A, 12kDa	transforming growth factor, beta receptor 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Terminal Cisterna Membrane Z Disc Sarcoplasmic Reticulum Membrane Axon Terminus Extracellular Vesicular Exosome	Cell Endosome Plasma Membrane Tight Junction Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signal Transducer Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Enzyme Binding Hsp70 Protein Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Ion Channel Binding SMAD Binding Activin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Receptor Signaling Protein Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Growth Factor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding I-SMAD Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Muscle Contraction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Response To Iron Ion Cytokine-mediated Signaling Pathway Protein Maturation By Protein Folding Response To Caffeine Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Protein Phosphatase Type 2B Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extracellular Fibril Organization Regulation Of Immune Response Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Activation Of MAPKK Activity Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Palate Development Pharyngeal System Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Response To Cholesterol Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs		Pimecrolimus Tacrolimus Sirolimus (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl-Beta-D-Glucopyranoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-Hydroxy-2-Butanone MYRISTIC ACID (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS			Age-related macular degeneration ( 23455636) Dental caries ( 23064961)
Protein-Protein Interactions		21 interactors: ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A DHFR FKBP4 GLMN ITPR1 MID1 MTOR PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	159 interactors: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K7 MYO3A MYOC NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP4 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZAK ZFYVE9
Entrez ID		2280	7046
HPRD ID		01741	01822
Ensembl ID		ENSG00000088832	ENSG00000106799
Uniprot IDs		P62942 Q0VDC6	P36897 Q5T7S2
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX	1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Transport Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Response To Stress Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Response To Abiotic Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Phosphorylation Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Localization To Nucleus Cell Differentiation Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Intracellular Transport Response To Stimulus Negative Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Differentiation Signal Transduction By Phosphorylation Regulation Of Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Chemical Homeostasis	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signal Transduction Response To Transforming Growth Factor Beta Signal Transduction Cell Communication Signaling Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Modification Process Regulation Of Signaling Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Organic Substance Protein Phosphorylation Phosphorylation Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Process Signal Transduction By Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Morphogenesis SMAD Protein Complex Assembly Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
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