FKBP1A and RYR3

Number of citations of the paper that reports this interaction (PMID 11171121)
17

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		FKBP1A	RYR3
Gene Name		FK506 binding protein 1A, 12kDa	ryanodine receptor 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Terminal Cisterna Membrane Z Disc Sarcoplasmic Reticulum Membrane Axon Terminus Extracellular Vesicular Exosome	Integral Component Of Membrane Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signal Transducer Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Enzyme Binding Hsp70 Protein Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Ion Channel Binding SMAD Binding Activin Binding	Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Binding Calmodulin Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Muscle Contraction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Response To Iron Ion Cytokine-mediated Signaling Pathway Protein Maturation By Protein Folding Response To Caffeine Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Protein Phosphatase Type 2B Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extracellular Fibril Organization Regulation Of Immune Response Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Calcium Ion Transport Striated Muscle Contraction Ion Transmembrane Transport Protein Homotetramerization Negative Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Ion channel transport Stimuli-sensing channels
Drugs		Pimecrolimus Tacrolimus Sirolimus (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl-Beta-D-Glucopyranoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-Hydroxy-2-Butanone MYRISTIC ACID (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS			Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		21 interactors: ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A DHFR FKBP4 GLMN ITPR1 MID1 MTOR PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	3 interactors: FKBP1A HNF1A RYR2
Entrez ID		2280	6263
HPRD ID		01741	01620
Ensembl ID		ENSG00000088832	ENSG00000198838
Uniprot IDs		P62942 Q0VDC6	Q15413
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX	4ERV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Transport Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Response To Stress Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Response To Abiotic Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Phosphorylation Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Localization To Nucleus Cell Differentiation Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Intracellular Transport Response To Stimulus Negative Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Differentiation Signal Transduction By Phosphorylation Regulation Of Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Chemical Homeostasis	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Muscle Tissue Morphogenesis Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Cation Channel Activity Chemical Homeostasis Enzyme Linked Receptor Protein Signaling Pathway Cardiac Ventricle Development Organ Morphogenesis Cardiac Chamber Development Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Alkaloid Left Ventricular Cardiac Muscle Tissue Morphogenesis Renal Glucose Absorption Positive Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Cardiac Muscle Tissue Development Regulation Of Calcium Ion Transport Homeostatic Process Positive Regulation Of Sequestering Of Calcium Ion Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Transport Muscle Contraction Heart Morphogenesis Negative Regulation Of Protein Phosphatase Type 2B Activity Amyloid Fibril Formation Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Muscle System Process Tissue Development Muscle Organ Development Ion Transport
Tagcloud ?			adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Difference) ?			adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Intersection) ?