ZBTB25 and CYP2J2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZBTB25	CYP2J2
Gene Name		zinc finger and BTB domain containing 25	cytochrome P450, family 2, subfamily J, polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Arachidonic Acid 14,15-epoxygenase Activity Arachidonic Acid 11,12-epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity Linoleic Acid Epoxygenase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression	Icosanoid Metabolic Process Xenobiotic Metabolic Process Regulation Of Heart Contraction Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APIP COIL CYP2J2 DDIT3 FCGR3A HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 TNIP1 TRAF2 TSSK3 ZBTB1	2 interactors: TCEB1 ZBTB25
Entrez ID		7597	1573
HPRD ID		01926	03159
Ensembl ID			ENSG00000134716
Uniprot IDs		P24278	P51589
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Signaling Protein Homooligomerization MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process MRNA Transcription Toll-like Receptor Signaling Pathway Protein Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Protein Homodimerization Activity Positive Regulation Of Immune Response Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Oligomerization Regulation Of Immune System Process Regulation Of Gene Expression Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Pro-T Cell Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Binding Positive Regulation Of Apoptotic Process	Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process
Tagcloud ?			25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp2c8 cyp2c9 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid ephx2 epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid
Tagcloud (Difference) ?			25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp2c8 cyp2c9 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid ephx2 epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid
Tagcloud (Intersection) ?