FARSA and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid, pull down)

		FARSA	ECSIT
Gene Name		phenylalanyl-tRNA synthetase, alpha subunit	ECSIT signalling integrator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation Gene Expression	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Phenylalanine
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		8 interactors: A2M ABI3 APOE ECSIT GORAB HNRNPR RNF32 TDGF1	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		2193	51295
HPRD ID		04227	12225
Ensembl ID		ENSG00000179115	ENSG00000130159
Uniprot IDs		B4E363 Q6IBR2 Q9Y285	K7EMM0 Q9BQ95
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of Epithelial Cell Migration Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Gastrulation Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization Regulation Of Catalytic Activity Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Beta-amyloid Clearance Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Regulation Of Inflammatory Response Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Phospholipid Transport Chylomicron Remnant Clearance Regulation Of MAP Kinase Activity Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Stem Cell Differentiation CGMP-mediated Signaling	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?			1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?			1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?