EPHB6 and HDHD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EPHB6	HDHD2
Gene Name		EPH receptor B6	haloacid dehalogenase-like hydrolase domain containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Ephrin Receptor Activity ATP Binding	Enzyme Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Axon Guidance Ephrin Receptor Signaling Pathway	Biological_process
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CBL CRK CRKL EFNB2 EPHB1 GRB2 HDHD2 INCA1 MLLT4 NIF3L1 NOTCH2NL REL SAT1 TCF4 TRIM39	12 interactors: BAI2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11
Entrez ID		2051	84064
HPRD ID		04133	13640
Ensembl ID		ENSG00000106123	ENSG00000167220
Uniprot IDs		O15197	Q9H0R4
PDB IDs			3HLT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Vessel Development Vasculature Development Ephrin Receptor Signaling Pathway Signaling Cell Communication Positive Regulation Of Intracellular Signal Transduction Cardiovascular System Development Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Process Activation Of MAPKK Activity Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis Regulation Of ERBB Signaling Pathway Spermidine Acetylation Catenin Import Into Nucleus 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Axon Guidance Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Dihydrobiopterin Metabolic Process Putrescine Catabolic Process Cell-cell Signaling Blood Vessel Morphogenesis Response To Stimulus Anatomical Structure Morphogenesis Maintenance Of DNA Repeat Elements Positive Regulation Of Metabolic Process Organ Morphogenesis Response To Organic Substance Oxalate Transport	Axon Guidance Neuron Development Axonogenesis Response To External Stimulus Axon Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Nervous System Development Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Neuron Projection Development Glutathione Metabolic Process Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cell Development Neurotransmitter Secretion Cell Morphogenesis Convergent Extension Involved In Neural Plate Elongation Targeting Of MRNA For Destruction Involved In RNA Interference Response To Silicon Dioxide Response To Magnetism System Development Secretion By Cell Cell Projection Organization Regulation Of Neurotransmitter Levels Collateral Sprouting Age-dependent Response To Oxidative Stress Production Of SiRNA Involved In RNA Interference Detection Of Oxygen Peptide Metabolic Process Locomotion Convergent Extension Involved In Organogenesis Somite Specification Response To Selenium Ion Ribonucleoprotein Complex Assembly Neurotransmitter Transport Secretion Multicellular Organismal Development Oxygen Homeostasis Pyrimidine Nucleobase Catabolic Process Protein Localization To Microtubule Platelet Activation RNA Interference
Tagcloud ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Difference) ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Intersection) ?