EPHA8 and ZNF746

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		EPHA8	ZNF746
Gene Name		EPH receptor A8	zinc finger protein 746
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection	Nucleus Cytoplasm
	Molecular Function	GPI-linked Ephrin Receptor Activity ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Death
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Generic Transcription Pathway
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		11 interactors: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 PIK3CG PSMC5 UBC ZNF746	13 interactors: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K7 PARK2 PRKRA RPS6KA6 ZAK
Entrez ID		2046	155061
HPRD ID		01493	08099
Ensembl ID		ENSG00000070886	ENSG00000181220
Uniprot IDs		P29322	Q6NUN9
PDB IDs		1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Axonogenesis Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Adhesion Locomotion Neuron Projection Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Movement Of Cell Or Subcellular Component Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Intracellular Signal Transduction Signal Transduction Involved In Cell Cycle Checkpoint Neuron Projection Development Regulation Of Cell Death T Cell Proliferation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Mitochondrial Asparaginyl-tRNA Aminoacylation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of MAPK Cascade Protein Phosphorylation Cellular Protein Modification Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Positive Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Axon Guidance Negative Regulation Of Phosphorylation Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Nervous System Development Cell Part Morphogenesis Response To Oxidative Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Negative Regulation Of MAPK Cascade Peptidyl-amino Acid Modification Neuron Development Response To Stimulus Regulation Of JNK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Stress-activated MAPK Cascade
Tagcloud ?			1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally
Tagcloud (Difference) ?			1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally
Tagcloud (Intersection) ?