ZNF746 and RPS6KA6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF746	RPS6KA6
Gene Name		zinc finger protein 746	ribosomal protein S6 kinase, 90kDa, polypeptide 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Death	Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Generic Transcription Pathway	Axon guidance RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		13 interactors: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K7 PARK2 PRKRA RPS6KA6 ZAK	28 interactors: ADIRF APP C14orf1 CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 FBN3 FZD5 LMO4 MAPK3 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		155061	27330
HPRD ID		08099	02250
Ensembl ID		ENSG00000181220
Uniprot IDs		Q6NUN9	Q9UK32
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Protein Phosphorylation Cellular Protein Modification Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Positive Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Axon Guidance Negative Regulation Of Phosphorylation Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Nervous System Development Cell Part Morphogenesis Response To Oxidative Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Negative Regulation Of MAPK Cascade Peptidyl-amino Acid Modification Neuron Development Response To Stimulus Regulation Of JNK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Stress-activated MAPK Cascade	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Processing Regulation Of Early Endosome To Late Endosome Transport Cell Differentiation Biosynthetic Process Cardiac Ventricle Development Negative Regulation Of Cellular Metabolic Process Labyrinthine Layer Blood Vessel Development Sterol Metabolic Process Tissue Development Cardiac Chamber Development Neuron Maturation Regulation Of Cell Fate Commitment Apoptotic Process Cell Maturation Negative Regulation Of Protein Processing Regulation Of Cellular Process Tissue Morphogenesis Programmed Cell Death Placenta Blood Vessel Development
Tagcloud ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Difference) ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally	anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Intersection) ?