TUBB and DPYSL2

Number of citations of the paper that reports this interaction (PMID 12134159)
111

Data Source:
HPRD (in vivo, in vitro)

		TUBB	DPYSL2
Gene Name		tubulin, beta class I	dihydropyrimidinase-like 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Mitochondrion Cytosol Microtubule Membrane Dendrite Growth Cone Neuronal Cell Body Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding	Dihydropyrimidinase Activity Protein Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Response To Amphetamine Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Regulation Of Neuron Projection Development Positive Regulation Of Glutamate Secretion Spinal Cord Development Olfactory Bulb Development Response To Cocaine Response To Drug Synaptic Vesicle Transport
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Axon guidance Semaphorin interactions L1CAM interactions CRMPs in Sema3A signaling Recycling pathway of L1
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	14 interactors: AP2A1 CRMP1 DISC1 DPYSL3 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB
Entrez ID		203068	1808
HPRD ID		01852	03914
Ensembl ID		ENSG00000196230	ENSG00000092964
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	Q16555 Q59GB4
PDB IDs		3QNZ 3QO0	2GSE 2VM8
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	Pyrimidine Nucleobase Catabolic Process Chemotaxis Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Neuron Differentiation Nervous System Development Cell Projection Organization Neuron Projection Development Pyrimidine Nucleobase Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Development Response To External Stimulus Cell Differentiation System Development Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Development Anatomical Structure Development Positive Regulation Of Cell Development Response To Stimulus Regulation Of Cell Differentiation Wnt Signaling Pathway Developmental Process Telencephalon Development Canonical Wnt Signaling Pathway Cytoskeleton Organization Forebrain Neuroblast Division Neural Precursor Cell Proliferation Regulation Of Neurogenesis Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Neurogenesis Positive Regulation Of Cell Differentiation Forebrain Development Somatic Stem Cell Division Cell Surface Receptor Signaling Pathway Organelle Organization Regulation Of Cell Projection Organization
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar
Tagcloud (Intersection) ?