MARK2 and MAPT

Number of citations of the paper that reports this interaction (PMID 24251416)
2

Data Source:
BioGRID (enzymatic study, x-ray crystallography)

		MARK2	MAPT
Gene Name		MAP/microtubule affinity-regulating kinase 2	microtubule-associated protein tau
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Basal Cortex Microtubule Bundle	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Poly(A) RNA Binding Tau-protein Kinase Activity	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding
	Biological Process	Mitochondrion Degradation Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement
Pathways			Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		23 interactors: BAIAP2 CAMK1 DVL3 GAB1 GSK3B HDAC7 KIF13B MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD6A PINK1 PKD1 PRKCE RAB11FIP2 RNF41 STK11 UTRN YWHAB YWHAQ YWHAZ	78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ
Entrez ID		2011	4137
HPRD ID		02753	01142
Ensembl ID		ENSG00000072518	ENSG00000186868
Uniprot IDs		A8K2S4 Q7KZI7	B3KTM0 P10636
PDB IDs		3IEC	1I8H 3FQP 3OVL 4GLR
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Cellular Localization Regulation Of Intracellular Transport Signaling Positive Regulation Of Signal Transduction Cell Communication Positive Regulation Of Transport Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Localization Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Neuron Projection Development Negative Regulation Of Transport Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Protein Modification Process Negative Regulation Of Sodium Ion Transport Regulation Of Establishment Of Protein Localization Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Regulation Of Cell Projection Organization Cell Death Death Response To Stimulus Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Sodium Ion Transport	Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction
Tagcloud ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel	1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants
Tagcloud (Difference) ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel	1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants
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