EIF5 and EIF1AX

Number of citations of the paper that reports this interaction (PMID 10982835)
24

Data Source:
HPRD (in vitro, in vivo)

		EIF5	EIF1AX
Gene Name		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 1A, X-linked
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytosol
	Molecular Function	Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Translation Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		14 interactors: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 NCBP2 NRGN PUM1	7 interactors: APP EIF2S1 EIF3C EIF5 EIF5B IKBKG IPO13
Entrez ID		1983	1964
HPRD ID		03417	02174
Ensembl ID		ENSG00000100664	ENSG00000173674
Uniprot IDs		P55010 Q6IBU0	P47813
PDB IDs		2E9H 2G2K 2IU1	1D7Q 3ZJY 4KZY 4KZZ
Enriched GO Terms of Interacting Partners?		Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Gene Expression MRNA 3'-end Processing Protein Metabolic Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Macromolecular Complex Assembly Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Axon Guidance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Collateral Sprouting In Absence Of Injury Cytokine-mediated Signaling Pathway Male Germ Cell Proliferation Regulation Of Metabolic Process Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Axonogenesis Cellular Component Assembly Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis MRNA Catabolic Process Axon Choice Point Recognition Axon Development RNA Processing Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cytoplasmic Translational Initiation Positive Regulation Of Glucokinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Chemotaxis Adiponectin-activated Signaling Pathway	Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Gene Expression Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Macromolecule Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Protein Phosphorylation Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Phosphorylation Biosynthetic Process Regulation Of Metabolic Process Cellular Copper Ion Homeostasis
Tagcloud ?		40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Difference) ?		40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Intersection) ?