EIF1AX and EIF5B

Number of citations of the paper that reports this interaction (PMID 12514125)
43

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		EIF1AX	EIF5B
Gene Name		eukaryotic translation initiation factor 1A, X-linked	eukaryotic translation initiation factor 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Translation Translational Initiation Gene Expression Cellular Protein Metabolic Process	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Translation GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		7 interactors: APP EIF2S1 EIF3C EIF5 EIF5B IKBKG IPO13	9 interactors: BRCA1 CBL CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 TFCP2 ZBTB3
Entrez ID		1964	9669
HPRD ID		02174	07304
Ensembl ID		ENSG00000173674	ENSG00000158417
Uniprot IDs		P47813	O60841 Q8N5A0
PDB IDs		1D7Q 3ZJY 4KZY 4KZZ
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Gene Expression Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Macromolecule Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Protein Phosphorylation Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Phosphorylation Biosynthetic Process Regulation Of Metabolic Process Cellular Copper Ion Homeostasis	Positive Regulation Of Histone H3-K4 Methylation Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Histone Modification Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Response To Abiotic Stimulus Response To Radiation Negative Regulation Of Cell Cycle Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Cell Cycle Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Transcription, DNA-templated Signal Transduction By P53 Class Mediator RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Angiogenesis Response To Hydrogen Peroxide Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally
Tagcloud (Difference) ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally
Tagcloud (Intersection) ?