EIF2B1 and RD3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF2B1	RD3
Gene Name		eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	retinal degeneration 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Visual Perception Response To Stimulus Retina Development In Camera-type Eye
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Retinopathy in non-diabetics ( 23393555)
Protein-Protein Interactions		14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1	3 interactors: APP EHMT2 EIF2B1
Entrez ID		1967	343035
HPRD ID		09458	12726
Ensembl ID			ENSG00000198570
Uniprot IDs		Q14232	Q7Z3Z2
PDB IDs		3ECS
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Translation DNA Methylation On Cytosine Within A CG Sequence Cell Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Metabolic Process Axon Choice Point Recognition Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Neuron Remodeling Histone H3-K27 Methylation Growth Regulation Of Translational Initiation In Response To Stress Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Regulation Of Translation In Response To Stress Cellular Copper Ion Homeostasis Negative Regulation Of Translational Initiation Histone H3-K9 Methylation Copper Ion Homeostasis Suckling Behavior Synaptonemal Complex Assembly Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Organization Sexual Reproduction Negative Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Histone H3-K9 Modification RNA Polyadenylation Neuron Recognition Central Nervous System Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Oligodendrocyte Development Positive Regulation Of Hydrolase Activity Reproduction Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Cellular Protein Metabolic Process
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	102t 5httlpr beck c4 caucasian character compassion comt cooperativeness dat depressiveness drd2 empathy ffi ht2a inventory maoa mentally mentioned neo neuroticism personality polish somatically spielberger temperament twin val158met vntr
Tagcloud (Difference) ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	102t 5httlpr beck c4 caucasian character compassion comt cooperativeness dat depressiveness drd2 empathy ffi ht2a inventory maoa mentally mentioned neo neuroticism personality polish somatically spielberger temperament twin val158met vntr
Tagcloud (Intersection) ?