EIF2B1 and ADRB2

Number of citations of the paper that reports this interaction (PMID 9235896)
9

Data Source:
HPRD (in vivo)

		EIF2B1	ADRB2
Gene Name		eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	adrenoceptor beta 2, surface
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1	88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		1967	154
HPRD ID		09458	00187
Ensembl ID			ENSG00000169252
Uniprot IDs		Q14232	P07550
PDB IDs		3ECS	1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell	Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Difference) ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Intersection) ?