EFNB2 and EPHB4

Number of citations of the paper that reports this interaction (PMID 9718367)
21

Data Source:
HPRD (in vivo)

		EFNB2	EPHB4
Gene Name		ephrin-B2	EPH receptor B4
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Cell-cell Signaling Axon Guidance Anatomical Structure Morphogenesis Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Viral Process Ephrin Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cardiac Muscle Cell Differentiation	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Axon Guidance Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Ephrin Receptor Signaling Pathway
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		21 interactors: DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RGS3 RHBDL2 SDCBP SRC	4 interactors: APP EFNB2 GRIN1 SDC3
Entrez ID		1948	2050
HPRD ID		02754	02481
Ensembl ID		ENSG00000125266	ENSG00000196411
Uniprot IDs		P52799	P54760 Q541P7 Q7Z635 Q96L35
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU	2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 4AW5 4BB4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Generation Of Neurons Neurogenesis Axonogenesis Cell Development Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Signaling Locomotion Cell Morphogenesis Involved In Differentiation Nervous System Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Cell Part Morphogenesis Dendritic Spine Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Differentiation Response To External Stimulus Cell Morphogenesis System Development Cell Migration Signal Transduction Synaptic Transmission Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Dendritic Spine Morphogenesis Cell Motility Regulation Of MAPK Cascade Multicellular Organismal Development Regulation Of Phosphorylation Signaling Cell Communication Anatomical Structure Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Synaptic Transmission Dendritic Spine Development Regulation Of Synaptic Plasticity Developmental Process Behavior	Suckling Behavior Response To Light Stimulus Mating Behavior Axon Guidance Ionotropic Glutamate Receptor Signaling Pathway Response To Radiation Mating Response To External Stimulus Glutamate Receptor Signaling Pathway Visual Learning Axonogenesis Visual Behavior Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Associative Learning Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Ephrin Receptor Signaling Pathway Feeding Behavior Cell Morphogenesis Involved In Differentiation Adult Locomotory Behavior Neuron Projection Development Propylene Metabolic Process Cell Projection Morphogenesis Neuromuscular Process Cell Part Morphogenesis Learning Neuron Development Adult Behavior Synaptic Growth At Neuromuscular Junction Olfactory Learning Cell Morphogenesis Response To Abiotic Stimulus Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Pons Maturation Locomotory Behavior Locomotion Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Manganese Ion Cognition Cellular Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Axon Choice Point Recognition
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	advantages autophosphorylation barely bhg712 explained fibroblasts fibrosarcoma heterogeneous intraperitoneal liposarcoma malignancies malignancy mesenchymal metastases mfh nvp residual sarcoma sarcomas soft spots sts summary synovial transmigration tumorigenesis vimentin vitality xenograft
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	advantages autophosphorylation barely bhg712 explained fibroblasts fibrosarcoma heterogeneous intraperitoneal liposarcoma malignancies malignancy mesenchymal metastases mfh nvp residual sarcoma sarcomas soft spots sts summary synovial transmigration tumorigenesis vimentin vitality xenograft
Tagcloud (Intersection) ?