PHC1 and SFMBT1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PHC1	SFMBT1
Gene Name		polyhomeotic homolog 1 (Drosophila)	Scm-like with four mbt domains 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Chromatin Binding Zinc Ion Binding	Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Multicellular Organismal Development Histone Ubiquitination Cellular Response To Retinoic Acid	Transcription, DNA-templated Spermatogenesis Chromatin Modification Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Organ Development
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Urate levels ( 23263486)
Protein-Protein Interactions		18 interactors: BMI1 GMNN HSPA8 PCGF2 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 SCMH1 SFMBT1 SIAH1 SP100 SUMO1 SUMO1P1 UBE2I ZCCHC7	6 interactors: ACP1 PHC1 PHC2 PSMA1 SRPK1 ZCCHC10
Entrez ID		1911	51460
HPRD ID		16009	09539
Ensembl ID		ENSG00000111752	ENSG00000163935
Uniprot IDs		B4DF21 J3KQH6 P78364 Q6GMQ3 Q6N083	Q9UHJ3
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Chromatin Modification Chromatin Organization Regulation Of Metabolic Process Anterior/posterior Pattern Specification Peptidyl-lysine Modification Protein Sumoylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Histone Ubiquitination Regulation Of RNA Metabolic Process Chromosome Organization Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Cellular Protein Modification Process Pattern Specification Process Cellular Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of Signaling Organelle Organization RNA Metabolic Process Histone Monoubiquitination Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Metabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cell Division Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	acquire carcinogenic catalyzing decipher demethylase demethylation dimethylated drivers emt ensuing h3k4me2 invasiveness kdm1a lsd1 lysines modifies nickel pollutant readers readouts recognizes recruiting represses reprogramming snai1 tgfbeta trimethyl unfavorable
Tagcloud (Difference) ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	acquire carcinogenic catalyzing decipher demethylase demethylation dimethylated drivers emt ensuing h3k4me2 invasiveness kdm1a lsd1 lysines modifies nickel pollutant readers readouts recognizes recruiting represses reprogramming snai1 tgfbeta trimethyl unfavorable
Tagcloud (Intersection) ?