DSC1 and DSG2

Number of citations of the paper that reports this interaction (PMID 9214392)
48

Data Source:
HPRD (in vivo, in vitro)

		DSC1	DSG2
Gene Name		desmocollin 1	desmoglein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding	Calcium Ion Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Response To Progesterone Maternal Process Involved In Female Pregnancy Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934)
Protein-Protein Interactions		8 interactors: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	5 interactors: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		1823	1829
HPRD ID		00511	00516
Ensembl ID		ENSG00000134765	ENSG00000046604
Uniprot IDs		Q08554 Q9HB00	Q14126
PDB IDs			2YQG
Enriched GO Terms of Interacting Partners?		Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Cell Adhesion Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Intermediate Filament Organization Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Cytoskeleton Organization Cell Junction Assembly Intermediate Filament-based Process Regulation Of Membrane Potential Intermediate Filament Bundle Assembly Adherens Junction Organization Regulation Of Actin Filament-based Process Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Response To Progesterone Ventricular Cardiac Muscle Tissue Development Cellular Component Assembly Cardiac Muscle Tissue Morphogenesis Apoptotic Process Programmed Cell Death Muscle Tissue Morphogenesis Cell Death Death Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cytoskeleton Organization Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Cardiac Ventricle Development Ventricular Compact Myocardium Morphogenesis Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cardiac Chamber Development	Desmosome Assembly Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cell Adhesion Regulation Of Striated Muscle Contraction Action Potential Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Muscle Contraction Regulation Of Heart Contraction Cell Junction Assembly Cell-cell Junction Organization Regulation Of Membrane Potential Regulation Of Actin Filament-based Process Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Cellular Component Movement Protein Localization To Plasma Membrane Endothelial Cell-cell Adhesion Adherens Junction Maintenance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Plasma Membrane Organization Establishment Of Protein Localization To Membrane Cellular Response To Indole-3-methanol Maintenance Of Organ Identity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Intermediate Filament Bundle Assembly Regulation Of Tight Junction Assembly Cytoskeletal Anchoring At Plasma Membrane Protein Localization To Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Endomembrane System Organization Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Cell Fate Specification Cellular Component Assembly Gap Junction Assembly Cellular Component Maintenance Regulation Of Cell Fate Commitment
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes