DYNC1LI2 and DMTN

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DYNC1LI2	DMTN
Gene Name		dynein, cytoplasmic 1, light intermediate chain 2	dematin actin binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane	Cytosol Actin Filament Plasma Membrane Endomembrane System Spectrin-associated Cytoskeleton Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Microtubule Motor Activity ATP Binding	Actin Binding Receptor Binding Protein Binding Spectrin Binding Protein Self-association
	Biological Process	Microtubule Cytoskeleton Organization Transport Microtubule-based Movement Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Centrosome Localization	Protein Complex Assembly Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP DMTN	13 interactors: ACTB ACTC1 APP DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB
Entrez ID		1783	2039
HPRD ID		09923	00506
Ensembl ID		ENSG00000135720	ENSG00000158856
Uniprot IDs		B4DZP4 O43237 Q63HJ8	B4DI75 Q08495
PDB IDs			1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Platelet Aggregation Protein Secretion By Platelet Synaptic Growth At Neuromuscular Junction Calcium-mediated Signaling Using Extracellular Calcium Source Negative Regulation Of Cell Development Exocytosis Collateral Sprouting In Absence Of Injury Actin Filament Reorganization Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Protein Targeting To Membrane Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Ketone Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Axon Choice Point Recognition Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Activation Secretion Neuron Remodeling Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Fibroblast Migration Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cell Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Peptidyl-threonine Phosphorylation Cellular Copper Ion Homeostasis Negative Regulation Of Focal Adhesion Assembly Copper Ion Homeostasis Suckling Behavior Regulation Of Lamellipodium Assembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Peptidyl-serine Phosphorylation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Fibroblast Migration Regulation Of Substrate Adhesion-dependent Cell Spreading Mating Behavior Regulation Of Integrin-mediated Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis	Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Tight Junction Assembly Cellular Response To Epinephrine Stimulus Response To Epinephrine Blood Coagulation Regulation Of Protein Binding Cell Maturation Hemostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Cellular Response To Catecholamine Stimulus Platelet Activation Ion Homeostasis Regulation Of Body Fluid Levels Cell Development Negative Regulation Of Transporter Activity Negative Regulation Of Nucleotide Metabolic Process Wound Healing Chemotaxis Regulation Of Binding Locomotion Cell Activation Immune Response Response To Wounding Regulation Of Cell Junction Assembly Water Homeostasis Homeostatic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Innate Immune Response Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Membrane Organization Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Morphogenesis Response To Interleukin-1 Regulation Of Striated Muscle Contraction Regulation Of Phospholipase Activity Negative Regulation Of Protein Polymerization Axon Guidance Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Tagcloud ?			apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Difference) ?			apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Intersection) ?