DMTN and EPB42

Number of citations of the paper that reports this interaction (PMID 8608138)
5

Data Source:
HPRD (in vivo)

		DMTN	EPB42
Gene Name		dematin actin binding protein	erythrocyte membrane protein band 4.2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Plasma Membrane Endomembrane System Spectrin-associated Cytoskeleton Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Perinuclear Region Of Cytoplasm	Cytoskeleton Plasma Membrane Cortical Cytoskeleton
	Molecular Function	Actin Binding Receptor Binding Protein Binding Spectrin Binding Protein Self-association	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Protein Complex Assembly Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Morphogenesis Regulation Of Cell Shape Peptide Cross-linking Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Iron Ion Homeostasis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTB ACTC1 APP DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB	13 interactors: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		2039	2038
HPRD ID		00506	01517
Ensembl ID		ENSG00000158856	ENSG00000166947
Uniprot IDs		B4DI75 Q08495	F5H563 P16452
PDB IDs		1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Tight Junction Assembly Cellular Response To Epinephrine Stimulus Response To Epinephrine Blood Coagulation Regulation Of Protein Binding Cell Maturation Hemostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Cellular Response To Catecholamine Stimulus Platelet Activation Ion Homeostasis Regulation Of Body Fluid Levels Cell Development Negative Regulation Of Transporter Activity Negative Regulation Of Nucleotide Metabolic Process Wound Healing Chemotaxis Regulation Of Binding Locomotion Cell Activation Immune Response Response To Wounding Regulation Of Cell Junction Assembly Water Homeostasis Homeostatic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Innate Immune Response Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Membrane Organization Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Morphogenesis Response To Interleukin-1 Regulation Of Striated Muscle Contraction Regulation Of Phospholipase Activity Negative Regulation Of Protein Polymerization Axon Guidance Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone	Movement Of Cell Or Subcellular Component Chemotaxis Locomotion Axon Guidance Neuron Projection Development Blood Coagulation Hemostasis Neuron Development Bicarbonate Transport Axonogenesis Cell Morphogenesis Ion Homeostasis Axon Development Cell Development Regulation Of Body Fluid Levels Response To External Stimulus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Plasma Membrane Wound Healing Erythrocyte Development Cell Projection Organization Regulation Of Intracellular PH Myeloid Cell Differentiation Regulation Of Cellular PH Neuron Projection Morphogenesis Actin Filament Capping Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Actin Filament Depolymerization Homeostatic Process Organelle Organization P38MAPK Cascade Positive Regulation Of Platelet Aggregation Protein Localization To T-tubule Muscle Cell Differentiation Vesicle-mediated Transport Regulation Of PH Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Establishment Of Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Cell Differentiation Chemical Homeostasis Cell Part Morphogenesis Generation Of Neurons Negative Regulation Of Protein Polymerization Protein Stabilization Protein Secretion By Platelet
Tagcloud ?		apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly
Tagcloud (Difference) ?		apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly
Tagcloud (Intersection) ?