AFP and PIDD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AFP	PIDD1
Gene Name		alpha-fetoprotein	p53-induced death domain protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleus Cytoplasm Golgi Apparatus
	Molecular Function	Metal Ion Binding	Death Receptor Binding Protein Binding
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Protein-Protein Interactions		10 interactors: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP	12 interactors: AFP CASP2 CCDC85B CRADD EFEMP2 FADD KEAP1 MADD MAFG MDFI SOX8 TEAD3
Entrez ID		174	55367
HPRD ID		00074	11284
Ensembl ID		ENSG00000081051	ENSG00000177595
Uniprot IDs		P02771	Q9HB75
PDB IDs		3MRK	2OF5
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Signal Transduction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Programmed Cell Death Regulation Of Signaling Cell Death Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Homeostasis Positive Regulation Of Protein Linear Polyubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Late Endosome To Golgi Transport Ion Homeostasis Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Mitotic Cell Cycle Checkpoint Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Cytosolic Calcium Ion Homeostasis Cardiac Muscle Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Apoptotic Process Regulation Of Protein Ubiquitination Endosomal Transport Regulation Of Cysteine-type Endopeptidase Activity Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Differentiation Response To Stimulus Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Reproductive System Development In Utero Embryonic Development Cellular Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Epidermal Cell Differentiation Development Of Primary Sexual Characteristics Protein Processing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Signaling Regulation Of Proteolysis Regulation Of Cellular Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Reproductive Process Cell Communication Regulation Of Metabolic Process Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Neural Retina Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Proteolysis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Chordate Embryonic Development Regulation Of Apoptotic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epidermis Development Positive Regulation Of Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Mitotic G1 DNA Damage Checkpoint Regulation Of Cell Death Apoptotic Signaling Pathway Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint
Tagcloud ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Difference) ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Intersection) ?