AFP and AP4S1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AFP	AP4S1
Gene Name		alpha-fetoprotein	adaptor-related protein complex 4, sigma 1 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Golgi Apparatus Coated Pit
	Molecular Function	Metal Ion Binding	Transporter Activity Protein Transporter Activity
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction	Protein Transport
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Protein-Protein Interactions		10 interactors: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP	6 interactors: AFP AP4E1 APP GRB2 GTF2I TEAD3
Entrez ID		174	11154
HPRD ID		00074	06257
Ensembl ID		ENSG00000081051	ENSG00000100478
Uniprot IDs		P02771	Q9Y587
PDB IDs		3MRK
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Signal Transduction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Programmed Cell Death Regulation Of Signaling Cell Death Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Homeostasis Positive Regulation Of Protein Linear Polyubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Late Endosome To Golgi Transport Ion Homeostasis Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Mitotic Cell Cycle Checkpoint Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Cytosolic Calcium Ion Homeostasis Cardiac Muscle Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Apoptotic Process Regulation Of Protein Ubiquitination Endosomal Transport Regulation Of Cysteine-type Endopeptidase Activity Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Reproductive Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Transition Between Slow And Fast Fiber Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Transcription Initiation From RNA Polymerase II Promoter Platelet Activation Collateral Sprouting Axon Midline Choice Point Recognition DNA-templated Transcription, Initiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Steroid Metabolic Process Positive Regulation Of Stem Cell Maintenance Regulation Of Skeletal Muscle Adaptation Cellular Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration Neuron Remodeling Calcium Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Signal Transduction Ovulation From Ovarian Follicle Signaling Axon Guidance Vesicle-mediated Transport Cell Communication Cellular Metal Ion Homeostasis Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Progesterone Metabolic Process Ovulation Metal Ion Homeostasis Labyrinthine Layer Morphogenesis Copper Ion Homeostasis Suckling Behavior
Tagcloud ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Difference) ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Intersection) ?