DCTN1 and BBS1

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		DCTN1	BBS1
Gene Name		dynactin 1	Bardet-Biedl syndrome 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Motor Activity Protein Binding Dynein Binding	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process	Retina Homeostasis Organelle Organization Visual Perception Nonmotile Primary Cilium Assembly Cilium Assembly Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Protein Localization To Cilium
Pathways		IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B	13 interactors: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7
Entrez ID		1639	582
HPRD ID		07206	01950
Ensembl ID		ENSG00000204843	ENSG00000174483
Uniprot IDs		Q14203 Q6MZZ3	E7EQH1 Q32MM9 Q8NFJ9
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Interleukin-8 Production Response To Organic Substance Cellular Response To Oxidative Stress Cellular Response To Organic Substance Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Optic Chiasma Development Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Optic Nerve Formation Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Golgi To Plasma Membrane CFTR Protein Transport Glycolate Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Cellular Response To Glyoxal Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Dismutase Activity Cellular Protein Metabolic Process Regulation Of Heart Rate Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Peptidyl-cysteine Oxidation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Regulation Of Superoxide Dismutase Activity Positive Regulation Of Cellular Metabolic Process Response To Oxidative Stress Cellular Response To Reactive Oxygen Species
Tagcloud ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a
Tagcloud (Difference) ?		als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sscp tulp1 ush2a
Tagcloud (Intersection) ?		sanger