BBS1 and BHMT

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		BBS1	BHMT
Gene Name		Bardet-Biedl syndrome 1	betaine--homocysteine S-methyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane	Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding	Zinc Ion Binding S-adenosylmethionine-homocysteine S-methyltransferase Activity Protein Complex Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Retina Homeostasis Organelle Organization Visual Perception Nonmotile Primary Cilium Assembly Cilium Assembly Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Protein Localization To Cilium	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Response To Organonitrogen Compound S-methylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium	Sulfur amino acid metabolism Metabolism of amino acids and derivatives
Drugs			L-Methionine S-(D-Carboxybutyl)-L-Homocysteine Citric Acid
Diseases
GWAS		Bipolar disorder ( 21926972)	Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610)
Protein-Protein Interactions		13 interactors: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7	5 interactors: ALG9 BBS1 BBS2 BBS4 LAMTOR3
Entrez ID		582	635
HPRD ID		01950	04200
Ensembl ID		ENSG00000174483	ENSG00000145692
Uniprot IDs		E7EQH1 Q32MM9 Q8NFJ9	E5RJH0 Q93088
PDB IDs			1LT7 1LT8
Enriched GO Terms of Interacting Partners?		Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Interleukin-8 Production Response To Organic Substance Cellular Response To Oxidative Stress Cellular Response To Organic Substance Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Optic Chiasma Development Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Optic Nerve Formation Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Golgi To Plasma Membrane CFTR Protein Transport Glycolate Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Cellular Response To Glyoxal Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Dismutase Activity Cellular Protein Metabolic Process Regulation Of Heart Rate Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Peptidyl-cysteine Oxidation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Regulation Of Superoxide Dismutase Activity Positive Regulation Of Cellular Metabolic Process Response To Oxidative Stress Cellular Response To Reactive Oxygen Species	Nonmotile Primary Cilium Assembly Photoreceptor Cell Maintenance Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Cellular Response To Leptin Stimulus Regulation Of Microtubule-based Movement Cilium Assembly Striatum Development Response To Leptin Visual Perception Sensory Perception Of Light Stimulus Tissue Homeostasis Cilium Organization Regulation Of Response To Food Cilium Morphogenesis Regulation Of Appetite Subpallium Development Golgi To Plasma Membrane Protein Transport Multicellular Organismal Homeostasis Cell Projection Assembly Golgi To Plasma Membrane Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Brain Morphogenesis Positive Regulation Of Multicellular Organism Growth Cellular Protein Localization Cellular Pigmentation Organelle Assembly Hippocampus Development Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Limbic System Development Regulation Of Multicellular Organism Growth Protein Localization Pigmentation Fat Cell Differentiation Spermatid Development Sensory Perception Spermatid Differentiation Protein Localization To Plasma Membrane Cell Projection Morphogenesis Positive Regulation Of Developmental Growth Cerebral Cortex Development Cell Part Morphogenesis
Tagcloud ?		abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a	1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike
Tagcloud (Difference) ?		abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a	1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike
Tagcloud (Intersection) ?