ADRA2C and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 11154706)
28

Data Source:
BioGRID (pull down)

		ADRA2C	PPP1R9B
Gene Name		adrenoceptor alpha 2C	protein phosphatase 1, regulatory subunit 9B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Axon Terminus	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Tizanidine Apomorphine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Iloperidone Asenapine Droxidopa Xylometazoline Lurasidone Agmatine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EIF2B1 GNAO1 PPP1R9B UCHL1 YWHAZ	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		152	84687
HPRD ID		00085	04506
Ensembl ID		ENSG00000184160	ENSG00000108819
Uniprot IDs		P18825 Q4W594	D3DTX6 Q96SB3
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Morphine Neurogenesis Response To Ammonium Ion Cell Development Response To Alkaloid Neuron Projection Development Response To Organonitrogen Compound Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Regulation Of Catalytic Activity Cellular Response To Morphine Neuron Development Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Locomotory Behavior Axon Transport Of Mitochondrion Neuron Differentiation Cell Projection Organization Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Translation In Response To Stress Histamine Secretion Cell Differentiation Response To Stress Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Generation Of Neurons Golgi Localization Regulation Of Translation In Response To Stress Filopodium Assembly Negative Regulation Of Translational Initiation Mast Cell Degranulation System Development Cellular Response To Ammonium Ion Response To Drug Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Stimulus Regulation Of Cellular Protein Metabolic Process Mast Cell Mediated Immunity Lysosome Localization Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Eating Behavior Mast Cell Activation	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?