ADRA2C

Gene Name		adrenoceptor alpha 2C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Axon Terminus
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Tizanidine Apomorphine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Iloperidone Asenapine Droxidopa Xylometazoline Lurasidone Agmatine
Diseases
GWAS
Protein-protein Interactions		5 interactors: EIF2B1 GNAO1 PPP1R9B UCHL1 YWHAZ
Entrez ID		152
HPRD ID		00085
Ensembl ID		ENSG00000184160
Uniprot IDs		P18825 Q4W594
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Morphine Neurogenesis Response To Ammonium Ion Cell Development Response To Alkaloid Neuron Projection Development Response To Organonitrogen Compound Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Regulation Of Catalytic Activity Cellular Response To Morphine Neuron Development Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Locomotory Behavior Axon Transport Of Mitochondrion Neuron Differentiation Cell Projection Organization Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Translation In Response To Stress Histamine Secretion Cell Differentiation Response To Stress Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Generation Of Neurons Golgi Localization Regulation Of Translation In Response To Stress Filopodium Assembly Negative Regulation Of Translational Initiation Mast Cell Degranulation System Development Cellular Response To Ammonium Ion Response To Drug Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Stimulus Regulation Of Cellular Protein Metabolic Process Mast Cell Mediated Immunity Lysosome Localization Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Eating Behavior Mast Cell Activation
Tagcloud ?		16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified