SMYD1 and ADSS

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SMYD1	ADSS
Gene Name		SET and MYND domain containing 1	adenylosuccinate synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	Magnesium Ion Binding Adenylosuccinate Synthase Activity Protein Binding GTP Binding Phosphate Ion Binding
	Biological Process	Chromatin Remodeling Transcription, DNA-templated Heart Development Positive Regulation Of Myotube Differentiation Histone Lysine Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated	Immune System Process Purine Nucleobase Metabolic Process AMP Biosynthetic Process Aspartate Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Purine-containing Compound 'de Novo' AMP Biosynthetic Process Small Molecule Metabolic Process IMP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Response To Ammonium Ion Cellular Response To Electrical Stimulus
Pathways			Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: ADSS BHLHE40 C11orf16 C11orf53 CCDC113 FAM204A H3F3C HDAC2 HDAC3 HOMEZ LENG8 MYH7B NACA OGDHL RBM4B TTC33 UTP14A WDR77 ZBTB44	2 interactors: ACTA1 SMYD1
Entrez ID		150572	159
HPRD ID		06025	00050
Ensembl ID		ENSG00000115593	ENSG00000035687
Uniprot IDs		E9PHG3 Q5HYE8 Q8NB12	P30520
PDB IDs			2V40
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Circadian Rhythm RNA Metabolic Process Rhythmic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H4 Deacetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Histone H3 Deacetylation Nitrogen Compound Metabolic Process Histone H3-K9 Modification Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Growth Regulation Of Transcription From RNA Polymerase II Promoter Histone Deacetylation Regulation Of Developmental Growth Protein Deacetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Response To Ammonium Ion Regulation Of Striated Muscle Cell Differentiation RNA Biosynthetic Process Regulation Of Circadian Rhythm Maintenance Of Chromatin Silencing 'de Novo' AMP Biosynthetic Process Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Striated Muscle Tissue Development Regulation Of Gene Expression Response To Abiotic Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development AMP Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Muscle Cell Differentiation Aspartate Metabolic Process Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cellular Metabolic Process Fungiform Papilla Morphogenesis	Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Muscle Organ Development Skeletal Muscle Fiber Adaptation Striated Muscle Tissue Development Muscle Tissue Development Muscle Structure Development Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Skeletal Muscle Adaptation Positive Regulation Of Myoblast Differentiation Skeletal Muscle Fiber Development Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Positive Regulation Of Myotube Differentiation Regulation Of Myoblast Differentiation Actin-mediated Cell Contraction Muscle Fiber Development Myotube Differentiation Regulation Of Myotube Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Actin Filament-based Movement Tissue Development Myofibril Assembly Positive Regulation Of Muscle Cell Differentiation Histone Lysine Methylation Peptidyl-lysine Methylation Regulation Of Striated Muscle Cell Differentiation Actomyosin Structure Organization Histone Methylation Cell Growth Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development
Tagcloud ?		adenosylhomocysteine autoinhibited autoinhibition away bend bending cochaperones crevice ctd ctds flexibility helices interdomain intradomain k4 lobed methylate move outwards restricts sinefungin smyd2 smyd3 stabilizes structurally superimposable tetratricopeptide tpr	acetylcholine ach alpha7 alphabtx bungarotoxin culminates diluted elucidation identifies kcs mek1 monolayers multifold nachr nachrs nicotine nicotinic nitrosamines pathobiologic periodontal phosphorylates pretreated proceeds pure raf retard sidestream stat tobacco
Tagcloud (Difference) ?		adenosylhomocysteine autoinhibited autoinhibition away bend bending cochaperones crevice ctd ctds flexibility helices interdomain intradomain k4 lobed methylate move outwards restricts sinefungin smyd2 smyd3 stabilizes structurally superimposable tetratricopeptide tpr	acetylcholine ach alpha7 alphabtx bungarotoxin culminates diluted elucidation identifies kcs mek1 monolayers multifold nachr nachrs nicotine nicotinic nitrosamines pathobiologic periodontal phosphorylates pretreated proceeds pure raf retard sidestream stat tobacco
Tagcloud (Intersection) ?