ADRA1D and SNTB1

Number of citations of the paper that reports this interaction (PMID 18468998)
17

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		ADRA1D	SNTB1
Gene Name		adrenoceptor alpha 1D	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Sarcolemma Protein Complex Synapse
	Molecular Function	Alpha1-adrenergic Receptor Activity	Actin Binding Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure DNA Metabolic Process G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Cell Proliferation Positive Regulation Of Cell Proliferation Adrenergic Receptor Signaling Pathway	Muscle Contraction
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs		Dapiprazole Amitriptyline Alfuzosin Norepinephrine Phenylephrine Promazine Prazosin Imipramine Nortriptyline Doxazosin Nicardipine Epinephrine Ergotamine Tamsulosin Propiomazine Doxepin Terazosin Pergolide Bromocriptine Quetiapine Methotrimeprazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS		Preeclampsia ( 23551011)	Myopia (pathological) ( 23406873)
Protein-Protein Interactions		8 interactors: ADRA1A FLNC LNX1 NOS1 SNTA1 SNTB1 SNTB2 SNTG1	11 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA KCNJ12 MAPK12 SCN4A SCN5A UTRN
Entrez ID		146	6641
HPRD ID		00079	02490
Ensembl ID		ENSG00000171873	ENSG00000172164
Uniprot IDs		B0ZBE0 P25100	Q13884
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Blood Pressure Regulation Of Vasoconstriction Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Serotonin Uptake Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Generation Of L-type Calcium Current Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of The Force Of Heart Contraction Pilomotor Reflex Regulation Of Blood Pressure Negative Regulation Of Peptidyl-cysteine S-nitrosylation Peptidyl-cysteine S-nitrosylation Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Striated Muscle Cell Differentiation Micturition Positive Regulation Of Cardiac Muscle Contraction Arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Action Potential Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Heart Rate Positive Regulation Of Guanylate Cyclase Activity Positive Regulation Of Striated Muscle Contraction Regulation Of Synaptic Transmission Blood Circulation Muscle Cell Differentiation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Nitric Oxide Biosynthetic Process Adrenergic Receptor Signaling Pathway	Muscle Contraction Muscle System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Sodium Ion Transport Regulation Of Ion Transport Signaling Cell Communication Action Potential Striated Muscle Contraction Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Muscle Organ Development Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Transmission Of Nerve Impulse Blood Circulation Heart Contraction Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cellular Process Regulation Of Striated Muscle Contraction Establishment Of Glial Blood-brain Barrier Peripheral Nervous System Development Membrane Depolarization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion G-protein Coupled Receptor Signaling Pathway Muscle Structure Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Membrane Depolarization During SA Node Cell Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Interleukin-1 Beta Secretion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synaptic Transmission Ion Transmembrane Transport Regulation Of Muscle Contraction SA Node Cell Action Potential Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier AV Node Cell To Bundle Of His Cell Communication Cellular Response To Stimulus
Tagcloud ?		aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Difference) ?		aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Intersection) ?