PIP5KL1 and PIP5K1B

Number of citations of the paper that reports this interaction (PMID 14701839)
4

Data Source:
HPRD (in vivo)

		PIP5KL1	PIP5K1B
Gene Name		phosphatidylinositol-4-phosphate 5-kinase-like 1	phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane Cell Projection	Uropod Cytosol Endomembrane System Membrane
	Molecular Function	ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity
	Biological Process	Phosphatidylinositol Phosphorylation	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways			Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Phospholipid metabolism Signaling by Wnt Signaling by WNT in cancer PI Metabolism
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594) Chronic kidney disease ( 20383146)
Protein-Protein Interactions		2 interactors: PIP5K1A PIP5K1B	2 interactors: BTK PIP5KL1
Entrez ID		138429	8395
HPRD ID		15139	04121
Ensembl ID		ENSG00000167103	ENSG00000107242
Uniprot IDs		Q5T9C9	B4DIG7 O14986 Q7KYT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol Phosphorylation Lipid Phosphorylation Phosphatidylinositol Biosynthetic Process Glycerophospholipid Biosynthetic Process Lipid Modification Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Biosynthetic Process Fibroblast Migration Activation Of Rac GTPase Activity Cellular Lipid Metabolic Process Ruffle Assembly Organophosphate Metabolic Process Focal Adhesion Assembly Lipid Metabolic Process Ruffle Organization Activation Of Rho GTPase Activity Protein Targeting To Plasma Membrane Adherens Junction Assembly Cell-substrate Junction Assembly Activation Of Ras GTPase Activity Positive Regulation Of Rac GTPase Activity Actin Cytoskeleton Reorganization Phosphorylation Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Keratinocyte Differentiation Small Molecule Metabolic Process Epidermal Cell Differentiation Protein Localization To Plasma Membrane Protein Targeting To Membrane Cell Chemotaxis Cell-matrix Adhesion Phosphate-containing Compound Metabolic Process Ameboidal-type Cell Migration Cell Junction Assembly	Regulation Of B Cell Cytokine Production Cellular Response To Molecule Of Fungal Origin Response To Molecule Of Fungal Origin Histamine Secretion By Mast Cell Histamine Secretion Positive Regulation Of B Cell Differentiation Histamine Transport Regulation Of B Cell Apoptotic Process Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of B Cell Differentiation Mast Cell Mediated Immunity Lysosome Localization Mast Cell Activation Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Response To Fungus Leukocyte Degranulation Regulated Secretory Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Lymphocyte Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Ammonium Transport Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Phosphorylation Toll-like Receptor 4 Signaling Pathway Hormone Secretion Phosphatidylinositol Phosphorylation Lipid Phosphorylation Hormone Transport Calcium-mediated Signaling Positive Regulation Of Lymphocyte Differentiation Cellular Response To Reactive Oxygen Species Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Activation Of Innate Immune Response Mesoderm Development Cell Maturation Regulation Of Lymphocyte Differentiation Leukocyte Activation Involved In Immune Response B Cell Activation Phosphate-containing Compound Metabolic Process
Tagcloud ?			affects ca1 ca3 cdna dentate differentially downregulated downregulation glutathione granular grb2 gstp2 gyrus help hippocampal hippocampus hybridization layer microarrays occurrence phosphate phosphatidylinositol pi2 pyramidal restraint reverse subjected transferase understand
Tagcloud (Difference) ?			affects ca1 ca3 cdna dentate differentially downregulated downregulation glutathione granular grb2 gstp2 gyrus help hippocampal hippocampus hybridization layer microarrays occurrence phosphate phosphatidylinositol pi2 pyramidal restraint reverse subjected transferase understand
Tagcloud (Intersection) ?