PIP5K1B

Gene Name		phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Uropod Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Phospholipid metabolism Signaling by Wnt Signaling by WNT in cancer PI Metabolism
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Chronic kidney disease ( 20383146)
Protein-protein Interactions		2 interactors: BTK PIP5KL1
Entrez ID		8395
HPRD ID		04121
Ensembl ID		ENSG00000107242
Uniprot IDs		B4DIG7 O14986 Q7KYT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of B Cell Cytokine Production Cellular Response To Molecule Of Fungal Origin Response To Molecule Of Fungal Origin Histamine Secretion By Mast Cell Histamine Secretion Positive Regulation Of B Cell Differentiation Histamine Transport Regulation Of B Cell Apoptotic Process Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of B Cell Differentiation Mast Cell Mediated Immunity Lysosome Localization Mast Cell Activation Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Response To Fungus Leukocyte Degranulation Regulated Secretory Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Lymphocyte Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Ammonium Transport Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Phosphorylation Toll-like Receptor 4 Signaling Pathway Hormone Secretion Phosphatidylinositol Phosphorylation Lipid Phosphorylation Hormone Transport Calcium-mediated Signaling Positive Regulation Of Lymphocyte Differentiation Cellular Response To Reactive Oxygen Species Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Activation Of Innate Immune Response Mesoderm Development Cell Maturation Regulation Of Lymphocyte Differentiation Leukocyte Activation Involved In Immune Response B Cell Activation Phosphate-containing Compound Metabolic Process
Tagcloud ?		affects ca1 ca3 cdna dentate differentially downregulated downregulation glutathione granular grb2 gstp2 gyrus help hippocampal hippocampus hybridization layer microarrays occurrence phosphate phosphatidylinositol pi2 pyramidal restraint reverse subjected transferase understand