NACC2 and EPS8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NACC2	EPS8
Gene Name		NACC family member 2, BEN and BTB (POZ) domain containing	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus NuRD Complex Nuclear Body	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Histone Deacetylase Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Posttranscriptional Regulation Of Gene Expression Histone Deacetylation Cellular Protein Complex Localization Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		5 interactors: EPS8 HDAC2 MTA1 MTA2 MTA3	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		138151	2059
HPRD ID		09831	02563
Ensembl ID		ENSG00000148411	ENSG00000151491
Uniprot IDs		Q96BF6	B4DX66 B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?		Chromatin Organization Regulation Of Gene Expression, Epigenetic Chromosome Organization Organelle Organization Histone Deacetylation Protein Deacetylation ATP-dependent Chromatin Remodeling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Autoubiquitination Circadian Rhythm Chromatin Remodeling Regulation Of Protein Autoubiquitination Maintenance Of Chromatin Silencing Actin Polymerization-dependent Cell Motility Locomotory Behavior Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Exit From Mitosis Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Rhythmic Process Negative Regulation Of Biosynthetic Process Fungiform Papilla Morphogenesis Behavioral Response To Ethanol Locomotor Rhythm Positive Regulation Of Receptor Biosynthetic Process Regulation Of Actin Cytoskeleton Organization Fungiform Papilla Development Regulation Of Sarcomere Organization Eyelid Development In Camera-type Eye Histone Modification Regulation Of Actin Filament-based Process Hair Follicle Placode Formation Positive Regulation Of Oligodendrocyte Differentiation Tongue Morphogenesis Negative Regulation Of Cardiac Muscle Tissue Development Single-organism Behavior Rac Protein Signal Transduction Regulation Of Receptor Biosynthetic Process Circadian Behavior Histone H4 Deacetylation Rhythmic Behavior Regulation Of Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Regulation Of Transcription, DNA-templated Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleic Acid-templated Transcription	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?