AGAP2 and PLCG1

Number of citations of the paper that reports this interaction (PMID 11823862)
44

Data Source:
HPRD (in vitro, in vivo)

		AGAP2	PLCG1
Gene Name		ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	phospholipase C, gamma 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Membrane Extracellular Vesicular Exosome	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection
	Molecular Function	Protein Binding GTP Binding ARF GTPase Activator Activity Zinc Ion Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Protein Transport Regulation Of ARF GTPase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity	Activation Of MAPKK Activity In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Viral Process Cell Migration Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Axon guidance Netrin-1 signaling	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		6 interactors: EPB41L1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1	106 interactors: ABL1 AGAP2 AGTR1 AKT1 ALK ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GNB2L1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PTK2 PTPN11 PTPRJ RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		116986	5335
HPRD ID		05687	01398
Ensembl ID		ENSG00000135439	ENSG00000124181
Uniprot IDs		F8VVT9 Q99490	P19174 Q4LE43 Q9UFY1
PDB IDs		2BMJ 2IWR 2RLO	1HSQ 2HSP 4EY0 4FBN
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Response To Cocaine Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Calcium Ion Transport Response To Ammonium Ion Calcium-mediated Signaling NFAT Protein Import Into Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration T Cell Receptor Signaling Pathway Regulation Of Ion Transport Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Transcription Factor Import Into Nucleus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Protein Stability Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Positive Regulation Of Transport Response To Alkaloid Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Adult Behavior Response To Organonitrogen Compound Tissue Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Regulation Of Protein Localization To Nucleus Positive Regulation Of Ion Transport Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Protein Autophosphorylation Fc Receptor Signaling Pathway Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Innate Immune Response Regulation Of Signal Transduction Response To Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Migration Cell Motility Response To Organic Substance Defense Response Regulation Of Immune Response Immune Response Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-amino Acid Modification Cellular Response To Growth Factor Stimulus Immune System Process Response To Wounding Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Substance Developmental Process Response To External Stimulus Wound Healing Protein Phosphorylation Regulation Of Catalytic Activity Phosphatidylinositol-mediated Signaling Cell Differentiation Regulation Of Cell Proliferation Peptidyl-tyrosine Autophosphorylation
Tagcloud ?			13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2
Tagcloud (Difference) ?			13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2
Tagcloud (Intersection) ?