AGAP2

Gene Name		ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding GTP Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Protein Transport Regulation Of ARF GTPase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-protein Interactions		6 interactors: EPB41L1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1
Entrez ID		116986
HPRD ID		05687
Ensembl ID		ENSG00000135439
Uniprot IDs		F8VVT9 Q99490
PDB IDs		2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Response To Cocaine Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Calcium Ion Transport Response To Ammonium Ion Calcium-mediated Signaling NFAT Protein Import Into Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration T Cell Receptor Signaling Pathway Regulation Of Ion Transport Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Transcription Factor Import Into Nucleus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Protein Stability Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Positive Regulation Of Transport Response To Alkaloid Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Adult Behavior Response To Organonitrogen Compound Tissue Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Regulation Of Protein Localization To Nucleus Positive Regulation Of Ion Transport Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
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