NOSTRIN and PRMT6

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		NOSTRIN	PRMT6
Gene Name		nitric oxide synthase trafficking	protein arginine methyltransferase 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoskeleton Plasma Membrane Endocytic Vesicle Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Endocytosis Signal Transduction Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking eNOS activation and regulation	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		4 interactors: APC KDM1A NOS3 PRMT6	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		115677	55170
HPRD ID		06324	10505
Ensembl ID		ENSG00000163072	ENSG00000198890
Uniprot IDs		Q8IVI9	Q96LA8
PDB IDs		2YUN	4HC4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H3-R2 Methylation Smooth Muscle Hyperplasia Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Organelle Organization Negative Regulation Of Signal Transduction Regulation Of Chromosome Organization Response To Stress Negative Regulation Of Signaling Smooth Muscle Adaptation Negative Regulation Of Odontogenesis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Metaphase/anaphase Transition Of Mitotic Cell Cycle Leukocyte Differentiation Histone H3-K9 Demethylation Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Histone H3-K4 Methylation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Histone H3-K4 Demethylation Arginine Catabolic Process Histone Modification Positive Regulation Of Megakaryocyte Differentiation Cell Development Negative Regulation Of Intracellular Signal Transduction Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Guanylate Cyclase Activity Blood Coagulation Hemostasis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Hormone Biosynthetic Process Ovulation From Ovarian Follicle Positive Regulation Of Microtubule Polymerization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?			bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?			bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?