PRMT6 and OAS1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	OAS1
Gene Name		protein arginine methyltransferase 6	2-5-oligoadenylate synthetase 1, 40/46kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Glucose Metabolic Process Purine Nucleotide Biosynthetic Process Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Glucose Homeostasis Negative Regulation Of Viral Genome Replication Protein Oligomerization Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)	Glycemic traits ( 23575436) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	6 interactors: ACTN1 EXOC5 PRMT6 RPL30 TRIM27 WBSCR22
Entrez ID		55170	4938
HPRD ID		10505	08879
Ensembl ID		ENSG00000198890	ENSG00000089127
Uniprot IDs		Q96LA8	P00973
PDB IDs		4HC4	4IG8
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Secretion By Cell Organelle Organization Secretion Histone H3-R2 Methylation Negative Regulation Of Interleukin-2 Secretion Protein Localization Establishment Of Localization In Cell Protein Localization To Tight Junction RNA Biosynthetic Process Cellular Localization Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protein Localization To Cell Junction Actin Filament Organization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Exocytosis Histone H4-R3 Methylation Protein Transport Negative Regulation Of Viral Release From Host Cell Vesicle-mediated Transport RNA Metabolic Process Establishment Of Protein Localization Peptidyl-arginine N-methylation Methylation Actin Crosslink Formation Intracellular Transport Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Gene Expression Histone Arginine Methylation Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Peptidyl-arginine Methylation Regulation Of Calcium Ion Import Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Viral Process Focal Adhesion Assembly Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Actin Cytoskeleton Organization Chromatin Modification Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Actin Filament-based Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Intersection) ?