CTRC and SERPINA3

Number of citations of the paper that reports this interaction (PMID 8718849)
7

Data Source:
HPRD (in vivo)

		CTRC	SERPINA3
Gene Name		chymotrypsin C (caldecrin)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component		Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways
Drugs
Diseases
GWAS			Body mass index ( 23669352)
Protein-Protein Interactions		8 interactors: KRTAP10-3 KRTAP10-7 NEDD8 PHKG1 SERPINA3 SPINK1 ST13 UBC	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		11330	12
HPRD ID		03242	00120
Ensembl ID		ENSG00000162438	ENSG00000196136
Uniprot IDs		Q99895	G3V5I3 P01011
PDB IDs		4H4F	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Glycogen Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Polysaccharide Metabolic Process Regulation Of Proteolysis Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Carbohydrate Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Protein Refolding Pathogenesis Hexose Metabolic Process Negative Regulation Of Calcium Ion Import Chaperone Cofactor-dependent Protein Refolding Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Serine-type Endopeptidase Activity Protein Neddylation Negative Regulation Of Serine-type Peptidase Activity Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Generation Of Precursor Metabolites And Energy Regulation Of Store-operated Calcium Entry Glycogen Catabolic Process Protein Refolding Epithelial Structure Maintenance Polysaccharide Catabolic Process Regulation Of Calcium Ion Import Notch Receptor Processing	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?