MED8 and MED19

Number of citations of the paper that reports this interaction (PMID 12584197)
12

Data Source:
HPRD (in vitro)

		MED8	MED19
Gene Name		mediator complex subunit 8	mediator complex subunit 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Nucleus Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49	11 interactors: APP DCK DHRS7B MED17 MED27 MED31 MED8 MED9 MSX1 NFKBIA RADIL
Entrez ID		112950	219541
HPRD ID		06991	17477
Ensembl ID		ENSG00000159479	ENSG00000156603
Uniprot IDs		Q96G25	A0JLT2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Development Regulation Of Binding Negative Regulation Of DNA Binding Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Regulation Of DNA Binding Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Synaptic Growth At Neuromuscular Junction Negative Regulation Of Binding Collateral Sprouting In Absence Of Injury Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Biosynthetic Process Stem Cell Maintenance Collateral Sprouting BMP Signaling Pathway Involved In Heart Development Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cytoplasmic Sequestering Of NF-kappaB Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft
Tagcloud (Intersection) ?