MED19 and DCK

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED19	DCK
Gene Name		mediator complex subunit 19	deoxycytidine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mediator Complex	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Deoxycytidine Kinase Activity ATP Binding Drug Binding Nucleoside Kinase Activity Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Purine Nucleobase Metabolic Process Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleotide Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Phosphorylation Pyrimidine Nucleoside Salvage Purine-containing Compound Salvage Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Pyrimidine salvage reactions Purine metabolism Pyrimidine metabolism Metabolism of nucleotides Purine salvage
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP DCK DHRS7B MED17 MED27 MED31 MED8 MED9 MSX1 NFKBIA RADIL	5 interactors: DDX19B GOLM1 MED19 RXRG TFEC
Entrez ID		219541	1633
HPRD ID		17477	00507
Ensembl ID		ENSG00000156603	ENSG00000156136
Uniprot IDs		A0JLT2	F5CTF3 P27707
PDB IDs			1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX 3IPY 3KFX 3MJR 3QEJ 3QEN 3QEO 4JLK 4L5B
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Development Regulation Of Binding Negative Regulation Of DNA Binding Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Regulation Of DNA Binding Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Synaptic Growth At Neuromuscular Junction Negative Regulation Of Binding Collateral Sprouting In Absence Of Injury Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Biosynthetic Process Stem Cell Maintenance Collateral Sprouting BMP Signaling Pathway Involved In Heart Development Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cytoplasmic Sequestering Of NF-kappaB Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process
Tagcloud ?		adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft	affects agent approved bcl2l10 cda common continued cr decitabine determine furthermore hent1 indicate induce level marrow mds measured mechanisms metabolic metabolism mrna regulated relapse resistance response secondary therapeutic underlying
Tagcloud (Difference) ?		adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft	affects agent approved bcl2l10 cda common continued cr decitabine determine furthermore hent1 indicate induce level marrow mds measured mechanisms metabolic metabolism mrna regulated relapse resistance response secondary therapeutic underlying
Tagcloud (Intersection) ?