SNF8 and CHMP6

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
HPRD (two hybrid)

		SNF8	CHMP6
Gene Name		SNF8, ESCRT-II complex subunit	charged multivesicular body protein 6
Image
Gene Ontology Annotations	Cellular Component	ESCRT II Complex Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Late Endosome Membrane Extracellular Vesicular Exosome	Cytosol Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Protein Homodimerization Activity	Protein Binding Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization Regulation Of Exosomal Secretion
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990)
Protein-Protein Interactions		15 interactors: ADORA1 CHMP6 DVL2 ELL GOLGA2 KDM1A NIF3L1 PRMT6 RILP SUV39H2 TRIM54 TSG101 VAC14 VPS25 VPS36	7 interactors: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36
Entrez ID		11267	79643
HPRD ID		16847	08564
Ensembl ID			ENSG00000176108
Uniprot IDs		Q96H20	Q96FZ7
PDB IDs		2ZME 3CUQ	2K3W 3HTU
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Circadian Rhythm Protein Localization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Protein Transport Regulation Of Gene Expression Regulation Of Metabolic Process Establishment Of Protein Localization Intracellular Transport Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity RNA Biosynthetic Process Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Establishment Of Localization In Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Histone H3-R2 Methylation Negative Regulation Of Mucus Secretion 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Circadian Rhythm Histone Modification Negative Regulation Of Binding RNA Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Long Term Synaptic Depression Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Endosomal Transport Vacuolar Transport Negative Regulation Of Autophagic Vacuole Assembly Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Organelle Late Endosome To Vacuole Transport Viral Budding Via Host ESCRT Complex Posttranslational Protein Targeting To Membrane Protein Targeting Viral Budding Protein Localization To Organelle Negative Regulation Of Macroautophagy Protein Transport Establishment Of Protein Localization Regulation Of Autophagic Vacuole Assembly Intracellular Transport Cell Separation After Cytokinesis Regulation Of Vacuole Organization Cytoplasmic Transport Protein Targeting To Vacuole Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Mitotic Metaphase Plate Congression Protein Localization Establishment Of Localization In Cell Metaphase Plate Congression Negative Regulation Of Autophagy Intracellular Protein Transport Establishment Of Chromosome Localization Cellular Localization Cellular Protein Localization Mitotic Sister Chromatid Segregation Membrane Budding Sister Chromatid Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Autophagy Protein Catabolic Process Nucleus Organization Protein Localization To Endoplasmic Reticulum Protein Targeting To Membrane Maintenance Of Lens Transparency Cellular Macromolecule Catabolic Process Viral Life Cycle Regulation Of Metabolic Process
Tagcloud ?		cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors	acting app bidirectional cleaving endocytosed endosomal endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn trafficking tsg101 uncertain vps35 vps4
Tagcloud (Difference) ?		cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors	acting app bidirectional cleaving endocytosed endosomal endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn trafficking tsg101 uncertain vps35 vps4
Tagcloud (Intersection) ?