SNF8 and TSG101

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
HPRD (two hybrid)

		SNF8	TSG101
Gene Name		SNF8, ESCRT-II complex subunit	tumor susceptibility 101
Image
Gene Ontology Annotations	Cellular Component	ESCRT II Complex Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Late Endosome Membrane Extracellular Vesicular Exosome	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Protein Homodimerization Activity	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990)
Protein-Protein Interactions		15 interactors: ADORA1 CHMP6 DVL2 ELL GOLGA2 KDM1A NIF3L1 PRMT6 RILP SUV39H2 TRIM54 TSG101 VAC14 VPS25 VPS36	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		11267	7251
HPRD ID		16847	03229
Ensembl ID			ENSG00000074319
Uniprot IDs		Q96H20	Q99816
PDB IDs		2ZME 3CUQ	1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Circadian Rhythm Protein Localization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Protein Transport Regulation Of Gene Expression Regulation Of Metabolic Process Establishment Of Protein Localization Intracellular Transport Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity RNA Biosynthetic Process Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Establishment Of Localization In Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Histone H3-R2 Methylation Negative Regulation Of Mucus Secretion 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Circadian Rhythm Histone Modification Negative Regulation Of Binding RNA Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Long Term Synaptic Depression Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?		cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?		cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?