KATNA1 and CLU

Number of citations of the paper that reports this interaction (PMID 17974975)
4

Data Source:
BioGRID (two hybrid)

		KATNA1	CLU
Gene Name		katanin p60 (ATPase containing) subunit A 1	clusterin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Lipid Particle Centrosome Microtubule Organizing Center Spindle Microtubule Plasma Membrane Axon Growth Cone Midbody Neuronal Cell Body	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Dynein Binding Protein Heterodimerization Activity	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Microtubule Bundle Formation Neuron Migration Mitotic Nuclear Division Protein Localization Metabolic Process Negative Regulation Of Neuron Projection Development Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		7 interactors: CLU DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1 VPRBP	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		11104	1191
HPRD ID		05986	01706
Ensembl ID		ENSG00000186625	ENSG00000120885
Uniprot IDs		A8K7S5 O75449	P10909
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Movement Cell Competition In A Multicellular Organism Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Histone H2A-T120 Phosphorylation Regulation Of Neuronal Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Neurofibrillary Tangle Assembly Organelle Organization Mitotic Cell Cycle Process Establishment Of Centrosome Localization Mitotic Chromosome Movement Towards Spindle Pole Diacylglycerol Catabolic Process Mitotic Cell Cycle Microtubule-based Process Central Nervous System Myelin Maintenance Intrinsic Apoptotic Signaling Pathway Regulation Of Tau-protein Kinase Activity Positive Regulation Of Microtubule Depolymerization Platelet Activating Factor Metabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Neuron Projection Development Immune System Process Long-chain Fatty Acid Catabolic Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Gliogenesis Lipid Catabolic Process Corpus Callosum Morphogenesis Mitotic Cell Cycle Phase Transition Osteoclast Development Positive Regulation Of Beta-amyloid Formation Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Protein Oligomerization Positive Regulation Of Cell Projection Organization Negative Regulation Of Beta-amyloid Formation Cytoplasmic MRNA Processing Body Assembly Retrograde Axon Cargo Transport Microtubule Severing Mitotic Nuclear Division Nuclear Migration Establishment Of Organelle Localization Positive Regulation Of Neuron Differentiation Leukocyte Differentiation Positive Regulation Of Glycogen Biosynthetic Process Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Alcohol Metabolic Process	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?			allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?			allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?