KATNA1 and KATNB1

Number of citations of the paper that reports this interaction (PMID 10751153)
32

Data Source:
HPRD (in vitro, in vivo)

		KATNA1	KATNB1
Gene Name		katanin p60 (ATPase containing) subunit A 1	katanin p80 (WD repeat containing) subunit B 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Lipid Particle Centrosome Microtubule Organizing Center Spindle Microtubule Plasma Membrane Axon Growth Cone Midbody Neuronal Cell Body	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Midbody Neuronal Cell Body
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Dynein Binding Protein Heterodimerization Activity	Microtubule Binding Microtubule-severing ATPase Activity Dynein Binding Protein Heterodimerization Activity
	Biological Process	Microtubule Bundle Formation Neuron Migration Mitotic Nuclear Division Protein Localization Metabolic Process Negative Regulation Of Neuron Projection Development Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Protein Targeting Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Microtubule Severing Cell Division
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CLU DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1 VPRBP	5 interactors: DYNC1H1 KATNA1 PAFAH1B1 TGFBR1 XRN1
Entrez ID		11104	10300
HPRD ID		05986	04081
Ensembl ID		ENSG00000186625	ENSG00000140854
Uniprot IDs		A8K7S5 O75449	Q9BVA0
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Movement Cell Competition In A Multicellular Organism Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Histone H2A-T120 Phosphorylation Regulation Of Neuronal Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Neurofibrillary Tangle Assembly Organelle Organization Mitotic Cell Cycle Process Establishment Of Centrosome Localization Mitotic Chromosome Movement Towards Spindle Pole Diacylglycerol Catabolic Process Mitotic Cell Cycle Microtubule-based Process Central Nervous System Myelin Maintenance Intrinsic Apoptotic Signaling Pathway Regulation Of Tau-protein Kinase Activity Positive Regulation Of Microtubule Depolymerization Platelet Activating Factor Metabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Neuron Projection Development Immune System Process Long-chain Fatty Acid Catabolic Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Gliogenesis Lipid Catabolic Process Corpus Callosum Morphogenesis Mitotic Cell Cycle Phase Transition Osteoclast Development Positive Regulation Of Beta-amyloid Formation Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Protein Oligomerization Positive Regulation Of Cell Projection Organization Negative Regulation Of Beta-amyloid Formation Cytoplasmic MRNA Processing Body Assembly Retrograde Axon Cargo Transport Microtubule Severing Mitotic Nuclear Division Nuclear Migration Establishment Of Organelle Localization Positive Regulation Of Neuron Differentiation Leukocyte Differentiation Positive Regulation Of Glycogen Biosynthetic Process Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Alcohol Metabolic Process	Cell Cycle Process Cell Cycle Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Mitotic Cell Cycle Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell Growth G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Cell Projection Organization Cell Migration Regulation Of Cell Development Neuron Migration Cell Motility Ameboidal-type Cell Migration Establishment Of Centrosome Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of Growth Platelet Activating Factor Metabolic Process Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Projection Organization Nuclear MRNA Surveillance Locomotion Negative Regulation Of Neurogenesis Corpus Callosum Morphogenesis Microtubule-based Movement Mitotic Nuclear Division Parathyroid Gland Development Osteoclast Development RNA Surveillance Negative Regulation Of Cell Development Histone MRNA Catabolic Process Regulation Of Cell Growth Cytoplasmic MRNA Processing Body Assembly Retrograde Axon Cargo Transport Microtubule Severing RRNA Catabolic Process Endothelial Cell Activation Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Nuclear Migration Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Neurogenesis
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